Gene ML1495c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in mycothiol biosynthesis. 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. Seems to possess weak mycothiol conjugate amidase activity but shows substantial deacetylation activity with 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins), a hypothetical mycothiol biosynthetic precursor. GlcNAc-Ins is an intermediate in MSH biosynthesis. |
| Product | N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) |
| Comments | ML1495c, len: 308 aa. Probable mshB, N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase. Highly similar to Mycobacterium tuberculosis Rv1170 TR:O50426 mshB (EMBL:AL010186) (303 aa), Fasta scores: E(): 0, 76.9% identity in 307 aa overlap and several proteins of unknown function including: Streptomyces lincolnensis LmbE TR:Q54358 (EMBL:X79146) (270 aa), Fasta scores: E(): 7.4e-13, 32.4% identity in 275 aa overlap and . Also similar to ML2391 from M. leprae. |
| Functional category | Conserved hypotheticals, Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1801892 | 1802818 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1495c|mshB
MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVQVVTCTLGEEGEVIGDRWAELTVDHADQLGGYRIFELTEALRALGVSAPIYLGGAGRWRDSGMRGTAPRRRQRFIDADENEAVGALVAIIRELRPHVVVTYDPHGGYGHPDHVHTHFITAAAVASSGVAAGLEVGADEYPGKPWKVPKFYWSVFALSAFEAGMNALQGKDLRPEWTIPPREEFYFGYSDKDIDAVVEATSDVWAAKTAALTAHATQVVVGPTGRACALSNNMVMPIFAQEHYVLAAGSAGNRDERGWETDLLAGLCLDGFDAR
Bibliography
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