Gene ML1511 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenpdA
Gene length708 bp
IdentifierML1511
Location 1821253 bp
Protein summary information
Molecular mass25871.4 Da
Isoelectric point5.57
Protein length236 amino acids
Structural information
PFAMPF02146
Orthologs
M. tuberculosis H37RvRv1151c
M. lepromatosis Mx1-22AMLPM_1511
Cross-references
UniProtQ9CBW6
Gene OntologyChromatin silencing, Cytoplasm, Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, Protein deacetylation, Zinc ion binding, Nad+ binding
Enzyme Classification3.5.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog)
CommentsML1511, len: 237 aa. Probable npdA, NAD-dependent deacetylase (EC 3.5.1.-). Highly similar to several e.g. Mycobacterium tuberculosis Rv1151c TR:O06549 (EMBL:Z95584) (237 aa), Fasta scores: E(): 0, 85.2% identity in 237 aa overlap and Q8NSM4|NPD_CORGL NAD-dependent deacetylase from Corynebacterium glutamicum (Brevibacterium flavum) (258 aa), fasta scores: E(): 2e-48, (46.610% identity in 236 aa overlap). Contains Pfam match to entry PF02146 SIR2, Sir2 family. Belongs to the sirtuin family.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18212531821960+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1511|npdA
VVVLSGAGISAESDVPTFRDDKNGLWARFDPYQLSSTQGWQRNPERVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEVSVITQNVDDLHERAGSTPVHHLHGSLFKFHCARCNVAYTGALPDMPEPVLEVDPPVCYCGGLIRPAIVWFGEPLPDEPWRRAVEATETTDVMVVVGTSAIVYPAAGLPELALSRGAVVIEVNPEPTPLTKNATISIRETASQALPGLLQRLPALLK
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