Gene ML1513c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedapA
Gene length903 bp
IdentifierML1513c
Location 1824631 bp
Protein summary information
Molecular mass31104.5 Da
Isoelectric point4.82
Protein length301 amino acids
Structural information
PFAMPF00701
Orthologs
M. tuberculosis H37RvRv2753c
M. lepromatosis Mx1-22AMLPM_1513
Cross-references
UniProtQ9CBW4
Gene OntologyDiaminopimelate biosynthetic process, 4-hydroxy-tetrahydrodipicolinate synthase, Cytoplasm
Enzyme Classification4.2.1.52
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE SYNTHETASE)
CommentsML1513c, len: 300 aa. Probable dapA, dihydrodipicolinate synthase (EC 4.2.1.52). Highly similar to many dihydrodipicolinate synthases including: Brevibacterium lactofermentum SW:DAPA_BRELA (P40109) (301 aa), Fasta scores: E(): 0, 58.0% identity in 288 aa overlap and Mycobacterium tuberculosis Rv2753c TR:O33295 (EMBL:AL008967) (300 aa), Fasta scores: E(): 0, 86.7% identity in 300 aa overlap. Contains Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family. Contains PS00665 Dihydrodipicolinate synthetase signature 1. Contains PS00666 Dihydrodipicolinate synthetase signature 2.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18246311825533-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1513c|dapA
VTTVGFDVPARLGTLLTAMVTPFDADGSVDTAAATRLANRLVDAGCDGLVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVRLVKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPGRSVVPIEPDTIRALASHPNIVGVKEAKADLYSGARIMADTGLAYYSGDDALNLPWLAVGAIGFISVISHLAAGQLRELLSAFGSGDITTARKINVAIGPLCSAMDRLGGVTMSKAGLRLQGIDVGDPRLPQMPATAEQIDELAVDMRAASVLR
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