Gene ML1556c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | IF-2, ONE OF THE ESSENTIAL COMPONENTS FOR THE INITIATION OF PROTEIN SYNTHESIS IN VITRO, PROTECTS FORMYLMETHIONYL-TRNA FROM SPONTANEOUS HYDROLYSIS AND PROMOTES ITS BINDING TO THE 30S RIBOSOMAL SUBUNITS. IT IS ALSO INVOLVED IN THE HYDROLYSIS OF GTP DURING THE FORMATION OF THE 70S RIBOSOMAL COMPLEX. |
| Product | PROBABLE TRANSLATION INITIATION FACTOR IF-2 INFB |
| Comments | ML1556c, len: 924 aa. Probable infB, initiation factor IF-2. Highly similar to Mycobacterium tuberculosis SW:IF2_MYCTU (P71613) (900 aa), Fasta scores: E(): 0, 83.6% identity in 933 aa overlap. Similar in the C-terminus to many translation initiation factors e.g. Bacillus subtilis SW:IF2_BACSU (P17889) (716 aa), Fasta scores: E(): 0, 45.5% identity in 686 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains Pfam match to entry PF02131 IF2, Initiation factor 2. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1880183 | 1882957 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1556c|infB
VAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSDAGGGNYRGGGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGEDQGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVLLTADAALDLRANSGMEAQGVAIEAHLDRGRGPVATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYELVEKQRA
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