Gene ML1577c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1577c
Gene length1827 bp
IdentifierML1577c
Location 1901941 bp
Protein summary information
Molecular mass64049.7 Da
Isoelectric point6.38
Protein length609 amino acids
Structural information
PFAMPF00905, PF05223
Orthologs
M. tuberculosis H37RvRv2864c
M. lepromatosis Mx1-22AMLPM_1577
Cross-references
UniProtQ9CBU6
Gene OntologyPeptidoglycan-based cell wall biogenesis, Response to antibiotic, Penicillin binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE PENICILLIN-BINDING LIPOPROTEIN
CommentsML1577c, len: 608 aa. Probable penicillin binding protein. Similar to many penicillin binding proteins e.g. Streptomyces clavuligerus high molecular weight group B penicillin binding protein TR:P72405 (EMBL:U56256) (551 aa), Fasta scores: E(): 6.3e-27, 29.9% identity in 609 aa overlap and Mycobacterium tuberculosis Rv2864c SW:O33346. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19019411903767-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1577c|ML1577c
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSDNPNEAHEALNAAWAGLQAGRLDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMVRYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNELGGSDVLVPGYLHHYALDATLAGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRLPGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEPSPASSVSITLDRFVQNAAQHAVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTGLFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRTILNYGGFDLGVVPMSRAFASSCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQGRVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNGTAKEIAGCCGAIFGKTGEAEFVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDYLT
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