Gene ML1581c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegcpE
Gene length1179 bp
IdentifierML1581c
Location 1905767 bp
Protein summary information
Molecular mass41382.3 Da
Isoelectric point5.82
Protein length393 amino acids
Structural information
PFAMPF04551
Orthologs
M. tuberculosis H37RvRv2868c
M. lepromatosis Mx1-22AMLPM_1581
Cross-references
UniProtQ9CBU5
Gene Ontology4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity, Iron ion binding, Oxidation-reduction process, Terpenoid biosynthetic process, 4 iron, 4 sulfur cluster binding
Enzyme Classification1.17.7.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GCPE PROTEIN
CommentsML1581c, len: 392 aa. Probable gcpE protein. Highly similar to many GcpE orthologues the function of which is unknown. However in E. coli gcpE has been shown to be an essential gene. Similar to Escherichia coli SW:GCPE_ECOLI (P27433) (372 aa), Fasta scores: E(): 0, 45.5% identity in 330 aa overlap and Mycobacterium tuberculosis Rv2868c TR:O33350 (EMBL:AL008883) (387 aa), Fasta scores: E(): 0, 87.6% identity in 388 aa overlap.
Functional categoryConserved hypotheticals
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19057671906945-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1581c|gcpE
VNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAELTTAGCDIVRVACPRQEDADALAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYGKATSEALVESALWEASLFEEHGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSKGIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAGLDGLEVPLRIAVMGCVVNGPGEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIEEAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN
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