Gene ML1583c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedxr
Gene length1221 bp
IdentifierML1583c
Location 1908221 bp
Protein summary information
Molecular mass42282.8 Da
Isoelectric point4.55
Protein length407 amino acids
Structural information
PFAMPF02670, PF08436
Orthologs
M. tuberculosis H37RvRv2870c
M. lepromatosis Mx1-22AMLPM_1583
Cross-references
UniProtQ9CBU3
Gene OntologyMetal ion binding, Oxidation-reduction process, Terpenoid biosynthetic process, 1-deoxy-d-xylulose-5-phosphate reductoisomerase activity
Enzyme Classification1.1.1.267
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE)
CommentsML1583c, len: 406 aa. Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.-). Highly similar to many 1-deoxy-D-xylulose 5-phosphate reductoisomerases involved in terpenoid biosynthesis e.g. Escherichia coli SW:DXR_ECOLI (P45568) (195 aa), BlastP Expect 9.4 and Mycobacterium tuberculosis Rv2870c SW:DXR_MYCTU (Q10798) (413 aa), Fasta scores: E(): 0, 84.3% identity in 395 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19082211909441-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1583c|dxr
VNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAATGVTNIAIADDRAAQLAGDIPYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTGARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVVVHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEPLDIDVFPAVELARHAGQIGGCMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQWAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSDMVLERS
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