Gene ML1589c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecdsA
Gene length939 bp
IdentifierML1589c
Location 1913904 bp
Protein summary information
Molecular mass32939.7 Da
Isoelectric point9.76
Protein length313 amino acids
Structural information
PFAMPF01148
Orthologues
M. tuberculosisRv2881c
Cross-references
UniProtQ9CBU1
Gene OntologyPhosphatidate cytidylyltransferase activity, Phospholipid biosynthetic process, Plasma membrane, Integral to membrane
Enzyme Classification2.7.7.41
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE CYTIDYLYLTRANSFERASE CDSA (CDP-DIGLYCERIDE SYNTHETASE) (CDP-DIGLYCERIDE PYROPHOSPHORYLASE) (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP:PHOSPHATIDATE CYTIDYLYLTRANSFERASE) (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE)
CommentsML1589c, len: 312 aa. Probable cdsA, integral membrane phosphatidate cytidylyltransferase (EC 2.7.7.41). Highly similar to several e.g. Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa), Fasta scores: E(): 0, 70.3% identity in 313 aa overlap and Q8FP76 Putative phosphatidate cytidylyltrans from Corynebacterium efficiens (297 aa), fasta score: E(): 6.2e-54, (48.986% identity in 296 aa overlap). Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase. Contains PS01315 Phosphatidate cytidylyltransferase signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19139041914842-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1589c|cdsA
VASTDPGTGTPLDESVPGIKRAMRQSTKNTPRAGRNLPAAIAVGLSIGGVLVATLVFAPRIWVVLCAGAIFVASHEVVRRLREAGYVIPAIPLLIGGQFTVWLTWPYRTVGALAGFGATVVVCMIWRLVMHDNSKQHESREALAGPPVSNYLRDASATVFLAAWVPLFASFAALLVYPKDGAGRVFCLMIAVVASDVGGYTVGVLFGKHPLVPRISPNKSWEGFAGSLVCGTTATILTATFLAGKTPWVGALLSFVLVLTCTLGDLVESQVKRDLGIKDMGRLLPGHGGLMDRLDGVLPSAVVAWTMLTLLP
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