Gene ML1591c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepyrH
Gene length840 bp
IdentifierML1591c
Location 1915490 bp
Protein summary information
Molecular mass29547.9 Da
Isoelectric point7.67
Protein length280 amino acids
Structural information
PFAMPF00696
Orthologues
M. tuberculosisRv2883c
Cross-references
UniProtO33045
Gene OntologyAtp binding, Ump kinase activity, Cellular amino acid biosynthetic process, Cytoplasm, Pyrimidine nucleotide biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process
Enzyme Classification2.7.4.22
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE URIDYLATE KINASE PYRH (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE)
CommentsML1591c, len: 279 aa. Probable pyrH, uridylate kinase uridylate kinase (EC 2.7.4.-). Highly similar to many uridylate kinases including: Escherichia coli SW:PYRH_ECOLI (P29464) (240 aa), Fasta scores: E(): 0, 46.1% identity in 232 aa overlap and Mycobacterium tuberculosis Rv2883c SW:PYRH_MYCTU (Q10791) (261 aa), Fasta scores: E(): 0, 85.0% identity in 274 aa overlap. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19154901916329-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1591c|pyrH
MTESWESQVAGSAVPKPQLMSANGVSAAAAGRGERLNHAGNPGHRSKYSRVLLKLGGEMFGGGQVGLDLDVVAQVARQIAEVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIATRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFVEDPRVNPEAELLTAISHREVIDRGLRVADATAFSLCMDNGMPILVFNLLTNGNIARAVAGEKIGTLVTT
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