Gene ML1596c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameamiC
Gene length1407 bp
IdentifierML1596c
Location 1920920 bp
Protein summary information
Molecular mass51164.1 Da
Isoelectric point7.22
Protein length469 amino acids
Structural information
PFAMPF01425
Orthologs
M. tuberculosis H37RvRv2888c
M. lepromatosis Mx1-22AMLPM_1596
Cross-references
UniProtO33040
Gene OntologyCarbon-nitrogen ligase activity, with glutamine as amido-n-donor, Amidase activity
Enzyme Classification3.5.1.4
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE AMIDASE AMIC (AMINOHYDROLASE)
CommentsML1596c, len: 468 aa. Probable amiC, amidase (EC 3.5.1.4). Highly similar to several proposed amidases including: Pseudomonas putida SW:AMID_PSEPU (O69768) (466 aa), Fasta scores: E(): 2.9e-19, 29.0% identity in 469 aa overlap and Mycobacterium tuberculosis Rv2888c SW:AMI3_MYCTU (Q10811) (473 aa), Fasta scores: E(): 0, 76.7% identity in 468 aa overlap. Contains Pfam match to entry PF01425 Amidase, Amidase. Contains PS00571 Amidases signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19209201922326-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1596c|amiC
MQRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAVNPALGGLAYEAFQWARQTASKAGSGFFSGVPTFIKDNIDVAGQPTMRGSDAWVPRNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAEHMRLGPVRNPWDTDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPASCNGLVGLKPSRGRLPLDSELRRLPVGIVVNGVLTRSVRDTAAFYREAERIWHNPKLPPVGDVTQPGRQRLRIAVVTRSVQRECSPELRELTLKSARLLEELGHRVERVAEPPVPPNFPDDFLLYWGLLAAMQVRTGRLAFGNTFDRTKLDSLTLGLDRHASRNMHRLPKAIMRLRRLRRRTADFFATYDVLLTPTVADETPRIGYLTPTDYQQVMDRLMGWVAFTPLQNVTGEPAISLPLAQSADGMPVGMMFTADFGQEAQLLELAFELEEARPWARIQIGD
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