Gene ML1612c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I). |
| Comments | ML1612c, len: 289 aa. Probable lepB, signal peptidase I (EC 3.4.21.89). Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa), Fasta scores: E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis Rv2903c SW:LEP_MYCTU (Q1078) (294 aa), Fasta scores: E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1936170 | 1937039 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1612c|lepB
VTETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILAVIAIGLYYVMLTFVARPYLIPSESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVFKGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNSTDVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ
Bibliography
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