Gene ML1623 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehtpG
Gene length1971 bp
IdentifierML1623
Location 1945512 bp
Protein summary information
Molecular mass73866.0 Da
Isoelectric point4.72
Protein length657 amino acids
Structural information
PFAMPF00183, PF02518
Orthologues
M. tuberculosisRv2299c
Cross-references
UniProtO33012
Gene OntologyCytoplasm, Protein folding, Response to stress, Unfolded protein binding, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)
CommentsML1623, len: 656 aa. Probable htpG, heat shock protein Hsp90 family. Highly similar to many heat shock 90 family proteins, including: Escherichia coli SW:HTPG_ECOLI (P10413) (624 aa), Fasta scores: E(): 0, 45.4% identity in 656 aa overlap and Mycobacterium tuberculosis Rv2299c SW:HTPG_MYCTU (Q50667) (647 aa), Fasta scores: E(): 0, 80.8% identity in 656 aa overlap. Contains 2 Pfam matches to entry PF00183 HSP90, Hsp90 protein. Contains PS00298 Heat shock hsp90 proteins family signature.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19455121947482+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1623|htpG
MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPRTVDTSDLHIEIEVDKNTRILTVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATRWSSDGEATYTIESVDEAPQGTSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGEEQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNSDAKIGMQLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQFGKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLLLTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHVKEVRLSTRLTESPACLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLAEGGALENPAKFAGLLADLLSRSM
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