Gene ML1637c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1637c
Gene length1116 bp
IdentifierML1637c
Location 1974017 bp
Protein summary information
Molecular mass39797.9 Da
Isoelectric point6.96
Protein length372 amino acids
Structural information
PFAMPF00075, PF00300
Orthologues
M. tuberculosisRv2228c
Cross-references
UniProtQ7AQ37
Gene OntologyRibonuclease h activity, Nucleic acid binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productconserved hypothetical protein
CommentsML1637c, len: 371 aa. Conserved hypothetical protein. HIghly similar to Mycobacterium tuberculosis hypothetical protein Rv2228c SW:YM28_MYCTU (Q10512) (364 aa), Fasta scores: E(): 0, 76.8% identity in 371 aa overlap. The N-terminus is similar to several ribonucleases e.g. Escherichia coli ribonuclease HI (EC 3.1.26.4) SW:RNH_ECOLI (P00647) (430 aa), BlastP Expect 8.7. The C-terminus is similar to many proteins belonging to the phosphoglycerate mutase family e.g. Escherichia coli SW:COBC_ECOLI (P52086) (430 aa), BlastP Expect 8.7. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.
Functional categoryConserved hypotheticals, Information pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19740171975132-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1637c|ML1637c
VKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDAVKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQTAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADLLGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVCSARARIIAEYQGETVLVVSHVTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGASSVRLVNQTGYL
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