Gene ML1655
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION. CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM MALONYL-ACP [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + MALONYL-[ACYL-CARRIER PROTEIN] = 3-OXOACYL-[ACYL-CARRIER PROTEIN] + [ACYL-CARRIER PROTEIN] + CO(2)]. |
| Product | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) |
| Comments | ML1655, len: 416 aa. Probable kasA, 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41). Highly similar to many 3-oxoacyl-[acyl-carrier-protein] synthases II involved in fatty acid biosynthesis including: Escherichia coli SW:FABF_ECOLI (P39435) (412 aa), Fasta scores: E(): 0, 41.1% identity in 411 aa overlap and Mycobacterium tuberculosis Rv2245 SW:FAB1_MYCTU (Q10524) (416 aa), Fasta scores: E(): 0, 92.5% identity in 416 aa overlap. Also highly similar to the adjoining CDS ML1655. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1994880 | 1996130 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1655|kasA
VTMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKIGGHLKEPVDSHMSRLDLRRMSYVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGACAGVMTPVSACSSGSEAIAHAWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFGEAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSAKDVDHVNAHGTATPIGDSAEANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINNSFGFGGHNVALAFGRY
Bibliography
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