Gene ML1657 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameaccD6
Gene length1422 bp
IdentifierML1657
Location 1997451 bp
Protein summary information
Molecular mass50278.1 Da
Isoelectric point6.68
Protein length474 amino acids
Structural information
PFAMPF01039
Orthologs
M. tuberculosis H37RvRv2247
M. lepromatosis Mx1-22AMLPM_1657
Cross-references
UniProtQ7AQ32
Gene OntologyLigase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6
CommentsML1657, len: 473 aa. Probable accD6, acetyl/propionyl CoA carboxylase [beta] subunit (EC 6.4.1.3). Highly similar to many propionyl-CoA carboxylases involved in fatty acid catabolism including: Rhodococcus erythropolis SW:PCCB_RHOER (Q06101) (476 aa), Fasta scores: E(): 0, 70.9% identity in 477 aa overlap and Mycobacterium tuberculosis Rv2247 SW:PCCB_MYCTU (Q10506) (473 aa), Fasta scores: E(): 0, 92.8% identity in 473 aa overlap. Also similar to ML0731 from M. leprae. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19974511998872+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1657|accD6
MTITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRRAYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKRKLAAAPNDEREALHDDLAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL
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