Gene ML1658c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN BASE EXCISION REPAIR (REPAIR OF OXIDIZED PURINES). THIS ENZYME MAY PLAY A SIGNIFICANT ROLE IN PROCESSES LEADING TO RECOVERY FROM MUTAGENESIS AND/OR CELL DEATH BY ALKYLATING AGENTS [CATALYTIC ACTIVITY HYDROLYSIS OF DNA CONTAINING RING-OPENED N7-METHYLGUANINE RESIDUES, RELEASING 2,6-DIAMINO-4-HYDROXY-5-(N-METHYL)FORMAMIDOPYRIMIDE]. |
| Product | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) |
| Comments | ML1658c, len: 282 aa. Probable formamidopyrimidine-DNA glycosylase (EC 3.2.2.23). Highly similar to many formamidopyrimidine-DNA glycosylases thought to be involved in DNA repair after exposure to alkylating agents e.g. Escherichia coli SW:FPG_ECOLI (P05523) (215 aa), BlastP Expect 8.7 and Mycobacterium tuberculosis SW:FPG_MYCTU (Q10959) (289 aa), Fasta scores: E(): 0, 80.6% identity in 289 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1999998 | 2000846 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1658c|fpg
MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRGKYLWFLLDTDIALVVHLGMSGQMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLADLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHSELKRQLLDQQTVSGIGNIYADEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFDRSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR
Bibliography
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