Gene ML1659c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namernc
Gene length717 bp
IdentifierML1659c
Location 2000901 bp
Protein summary information
Molecular mass25208.4 Da
Isoelectric point5.09
Protein length239 amino acids
Structural information
PFAMPF00035, PF00636
Orthologs
M. tuberculosis H37RvRv2925c
M. lepromatosis Mx1-22AMLPM_1659
Cross-references
UniProtO69469
Gene OntologyDouble-stranded rna binding, Mrna processing, Rrna catabolic process, Rrna processing, Ribonuclease iii activity, Cytoplasm
Enzyme Classification3.1.26.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE RIBONUCLEASE III RNC (RNASE III)
CommentsML1659c, len: 238 aa. Probable rnc, Ribonuclease III (EC 3.1.26.3). Highly similar to many ribonucleases involved in the digestion of double stranded RNA e.g. Escherichia coli SW:RNC_ECOLI (P05797) (226 aa), Fasta scores: E(): 1e-24, 41.8% identity in 213 aa overlap and Mycobacterium tuberculosis Rv2925c SW:RNC_MYCTU (Q10962) (240 aa), Fasta scores: E(): 0, 86.8% identity in 235 aa overlap. Contains Pfam match to entry PF00035 dsrm, Double-stranded RNA binding motif. Contains Pfam match to entry PF00636 Ribonuclease_3, RNase3 domain.. Contains PS00517 Ribonuclease III family signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20009012001617-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1659c|rnc
VTQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELFHRHPDRSEGDLAKLRASVVNTQALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILADGMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGLDWKTSLQELTAARGMGVPSYVVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV
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