Gene ML1684c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuD
Gene length597 bp
IdentifierML1684c
Location 2029540 bp
Protein summary information
Molecular mass22136.3 Da
Isoelectric point5.74
Protein length199 amino acids
Structural information
PFAMPF00694
Orthologues
M. tuberculosisRv2987c
Cross-references
UniProtO33124
Gene Ontology3-isopropylmalate dehydratase complex, Leucine biosynthetic process, 3-isopropylmalate dehydratase activity
Enzyme Classification4.2.1.33
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI)
CommentsML1684c, len: 198 aa. Probable leuD, 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33). Highly similar to many 3-isopropylmalate dehydratase small subunits involved in leucine biosynthesis, including: Escherichia coli SW:LEUD_ECOLI (P30126) (201 aa), Fasta scores: E(): 1.2e-28, 42.1% identity in 197 aa overlap and Mycobacterium tuberculosis Rv2987c SW:LEUD_MYCTU (O53236) (198 aa), Fasta scores: E(): 0, 87.8% identity in 196 aa overlap. Contains Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20295402030136-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1684c|leuD
MQAFRVHTGIGVPLRRSNVDTDQIIPAVFLKRVTRNGFEDGLFATWRVDPSFVLNLSPFDRGSVLVVGPDFGIGSSREHAVWALMDYGFRVVISSRFGDIFHGNAGKAGLLAAQVAQDDVEFLWKLIEQKPGLEITVNLQDRNINAATVVLPFKIDDYTAWRLLEGLDDIALNLRKLDEIEAFESARPAWKPRTLPTT
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