Gene ML1692c (serA) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameserA1
Gene length1587 bp
IdentifierML1692c
Location 2038222 bp
Protein summary information
Molecular mass54437.0 Da
Isoelectric point4.59
Protein length529 amino acids
Structural information
PFAMPF00389, PF01842, PF02826
Orthologs
M. tuberculosis H37RvRv2996c
M. lepromatosis Mx1-22AMLPM_1692
Cross-references
UniProtO33116
Gene OntologyNad binding, Amino acid binding, Oxidation-reduction process, Phosphoglycerate dehydrogenase activity, L-serine biosynthetic process
Enzyme Classification1.1.1.95
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)
CommentsML1692c, len: 528 aa. Probable serA1, D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95). Highly similar to many D-3-phosphoglycerate dehydrogenases involved in serine biosynthesis including: Bacillus subtilis SW:SERA_BACSU (P35136) (525 aa), Fasta scores: E(): 0, 36.1% identity in 527 aa overlap and Mycobacterium tuberculosis Rv2996c SW:SERA_MYCTU (O53243) (528 aa), Fasta scores: E(): 0, 89.6% identity in 528 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. Contains PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20382222039808-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1692c|serA1
VDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADASLRAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATEPCTDSPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
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