Gene ML1694c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameilvC
Gene length1002 bp
IdentifierML1694c
Location 2042727 bp
Protein summary information
Molecular mass36198.0 Da
Isoelectric point4.61
Protein length334 amino acids
Structural information
PFAMPF01450, PF07991
Orthologs
M. tuberculosis H37RvRv3001c
M. lepromatosis Mx1-22AMLPM_1694
Cross-references
UniProtO33114
Gene OntologyIsoleucine biosynthetic process, Ketol-acid reductoisomerase activity, Oxidation-reduction process, Valine biosynthetic process, Binding
Enzyme Classification1.1.1.86
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)
CommentsML1694c, len: 333 aa. Probable ilvC, ketol-acid reductoisomerase (EC1.1.1.86 ). Highly similar to many ketol-acid reductoisomerases involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVC_MYCAV (Q59500) (333 aa), Fasta scores: E(): 0, 89.2% identity in 333 aa overlap and Mycobacterium tuberculosis Rv3001c SW:ILVC_MYCTU (O53248) (333 aa), Fasta scores: E(): 0, 86.2% identity in 333 aa overlap. Contains Pfam match to entry PF01450 IlvC, Acetohydroxy acid isomeroreductase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20427272043728-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1694c|ilvC
LFYDDNADLSIIQRRKVGVIGYGSQGYAHSLSLRDSGVQVRVGLPEGSKSRPKAFEQGLDVDTPAEVAKWADVIMLLVPDTAQADVFENDIEPNLQPGDALFFGHGLNIHFELVKPSGDVTVAMVAPKGPGYLVRRQFVDGKGVPCLIAVNQDPTGTGEALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDADTKERMRGILRDIQDGSFVKKLVANVEGGNKQLEVLRKENAEHPIEVTGKKLRDLMSWVDRQSTETA
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