Gene ML1708c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameiscS
Gene length1233 bp
IdentifierML1708c
Location 2060896 bp
Protein summary information
Molecular mass42737.8 Da
Isoelectric point6.27
Protein length411 amino acids
Structural information
PFAMPF00266
Orthologs
M. tuberculosis H37RvRv3025c
M. lepromatosis Mx1-22AMLPM_1708
Cross-references
UniProtQ9CBR5
Gene OntologyPyridoxal phosphate binding, Transaminase activity, Metabolic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) (NITROGENASE METALLOCLUSTERS BIOSYNTHESIS PROTEIN NIFS)
CommentsML1708c, len: 410 aa. Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-). Highly similar to Mycobacterium tuberculosis NifS-like protein Rv3025c TR:O53272 (EMBL:AL021287) (393 aa), Fasta scores: E(): 0, 84.9% identity in 391 aa overlap and many aminotransferases resembling NifS e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa), Fasta scores: E(): 0, 39.1% identity in 394 aa overlap. Also similar to ML0596 from M. leprae. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20608962062128-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1708c|iscS
LIRQAPIAGILKCVMAYLDHAATTPMHPAAIEAMTTALGTVGNASSLHTSGRVARRRIEESRELIADKLAARPSEVIFTAGGTESDNLAVKGIYWARRDAQPCHRRIVTTEVEHHAVLDSVNWLVEHEGAEVTWLPTAADGSVSAFGLREALQQHNDVALVSVMWANNEVGTVMPVVELAAVAAEFGVPMHSDAIQAVGQLPVKFGVSGLSAMSVAAHKFGGPPGVGALLLRRDISCVPLLHGGGQERDIRSGTPGVASVVGMAAAAQIAVDGLEINSIRLQVLRDRLIEGVLATIDDVALNGARDRMRLPGNAHFIFRGCEGDVLLMLLDANGIECSTGSACTSGVPQPSHVLIAMGADPASARGSLRLSLGHNSVEVDVEEVLRVLPGAVDRARRASLAAAGAGGVGV
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