Gene ML1728c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1-3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. CO I IS THE CATALYTIC SUBUNIT OF THE ENZYME. ELECTRONS ORIGINATING IN CYTOCHROME C ARE TRANSFERRED VIA THE COPPER A CENTER OF SUBUNIT 2 AND HEME A OF SUBUNIT 1 TO THE BIMETALLIC CENTER FORMED BY HEME A3 AND COPPER B [CATALYTIC ACTIVITY: 4 FERROCYTOCHROME C + O(2) = 2 H(2)O + 4 FERRICYTOCHROME C]. |
| Product | PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) |
| Comments | ML1728c, len: 574 aa. Probable ctaD, cytochrome C oxidase, polypeptide I (EC 1.9.3.1). Highly similar to many cytochrome C oxidases including: Bacillus firmus SW:COX1_BACFI (Q04440) (624 aa), Fasta scores: E(): 0, 51.9% identity in 522 aa overlap and Mycobacterium tuberculosis Rv3043c SW:COX1_MYCTU (O53290) (573 aa), Fasta scores: E(): 0, 95.4% identity in 566 aa overlap. Contains Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I. Contains PS00077 Heme-copper oxidase catalytic subunit. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2084630 | 2086354 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1728c|ctaD
LTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDAIHSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHLGAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHYVLFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIGSFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRDEAYVGRRHAEELVEVSLH
Bibliography
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