Gene ML1730 (adhA) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameadhC
Gene length1089 bp
IdentifierML1730
Location 2087923 bp
Protein summary information
Molecular mass38907.6 Da
Isoelectric point7.56
Protein length363 amino acids
Structural information
PFAMPF00107, PF08240
Orthologs
M. tuberculosis H37RvRv3045
M. lepromatosis Mx1-22AMLPM_1730
Cross-references
UniProtQ9CBQ3
Gene OntologyOxidoreductase activity, Zinc ion binding, Oxidation-reduction process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC
CommentsML1730, len: 362 aa. Probable adhC, NADP-dependent alcohol dehydrogenase (EC 1.1.1.2). Highly similar to many Prokaryotic and Eukaryotic dehydrogenases including: Mycobacterium tuberculosis Rv3045 SW:ADH_MYCTU (P31975) (346 aa), Fasta scores: E(): 0, 85.8% identity in 346 aa overlap and Arabidopsis thaliana SW:CAD1_ARATH (P42734) (360 aa), Fasta scores: E(): 0, 48.8% identity in 344 aa overlap. Also similar to ML2053 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Note previously known as adhA.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20879232089011+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1730|adhC
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHIPDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYATADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALMRRSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL
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