Gene ML1731c (nrdF2)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE DNA REPLICATION PATHWAY. CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE NECESSARY FOR DNA SYNTHESIS [CATALYTIC ACTIVITY: 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN]. |
| Product | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) |
| Comments | ML1731c, len: 325 aa. Probable nrdF, ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1). Highly similar to many ribonucleoside-diphosphate reductase 2 beta chains, involved in DNA replication, including: Escherichia coli SW:RIR4_ECOLI (P37146) (319 aa), Fasta scores: E(): 0, 71.6% identity in 320 aa overlap and Mycobacterium tuberculosis Rv3048c TR:Q50549 (EMBL:AL021287) (324 aa), Fasta scores: E(): 0, 93.5% identity in 324 aa overlap. Contains Pfam match to entry PF00268 ribonuc_red, Ribonucleotide reductases. Contains PS00368 Ribonucleotide reductase small subunit signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2090620 | 2091597 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1731c|nrdF
LLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEVEYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
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