Gene ML1734c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenrdE
Gene length2082 bp
IdentifierML1734c
Location 2094331 bp
Protein summary information
Molecular mass79070.5 Da
Isoelectric point6.73
Protein length694 amino acids
Structural information
PFAMPF00317, PF02867, PF08343
Orthologs
M. tuberculosis H37RvRv3051c
M. lepromatosis Mx1-22AMLPM_1734
Cross-references
UniProtQ9CBQ0
Gene OntologyDna replication, Oxidation-reduction process, Protein binding, Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor, Ribonucleoside-diphosphate reductase complex, Atp binding
Enzyme Classification1.17.4.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN THE DNA REPLICATION PATHWAY. CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE NECESSARY FOR DNA SYNTHESIS. [CATALYTIC ACTIVITY: 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN].
ProductRIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)
CommentsML1734c, len: 693 aa. Probable nrdE, ribonucleoside diphosphate reductase [alpha] chain (EC 1.17.4.1). Highly similar to Mycobacterium tuberculosis ribonucleoside-diphosphate reductase alpha chain (EC 1.17.4.1) Rv3051c SW:RIR1_MYCTU (P50640) (693 aa), Fasta scores: E(): 0, 93.2% identity in 693 aa overlap. Contains Pfam match to entry PF00317 ribonucleo_red, Ribonucleotide reductase. Contains PS00089 Ribonucleotide reductase large subunit signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20943312096412-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1734c|nrdE
MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFSTFLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGDTGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSVNSALQLSKRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVPFADISVTEKYYEMLDDARIRKTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTVEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTVLFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIPTQNDWKRLKELVVAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL
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