Gene ML1795 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehsp18
Gene length447 bp
IdentifierML1795
Location 2174304 bp
Protein summary information
Molecular mass16706.9 Da
Isoelectric point4.78
Protein length149 amino acids
Structural information
PFAMPF00011
Cross-references
UniProtP12809
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Product18 KDA antigen Hsp18 (HSP 16.7)
CommentsML1795, len: 148 aa. hsp18, 18 KDA antigen. Highly similar to other mycobacterial antigens e.g. 18K1_MYCIT|P46730 18 kDa antigen 1 from Mycobacterium intracellulare (149 aa), Fasta scores: E(): 0, (78.7% identity in 150 aa overlap), and small heat shock proteins e.g. HS18_STRAL|Q53595 hsp18 from Streptomyces albus (143 aa), Fasta scores: E(): 4.1e-26, (55.0% identity in 140 aa overlap). Previously sequenced as 18KD_MYCLE|P12809 (148 aa), Fasta scores: E(): 0, 100.0% identity in 148 aa overlap. Contains Pfam match to entry PF00011 HSP20, Hsp20/alpha crystallin family. Belongs to the small heat shock protein (HSP20) family.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21743042174750+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1795|hsp18
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERNVVTVRAERPGVDPDREMLAAERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAERAKPRKISVDRGNNGHQTINKTAHEIIDA
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