Gene ML1799c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemutB
Gene length2277 bp
IdentifierML1799c
Location 2177910 bp
Protein summary information
Molecular mass81641.1 Da
Isoelectric point5.79
Protein length759 amino acids
Structural information
PFAMPF01642, PF02310
Orthologs
M. tuberculosis H37RvRv1493
M. lepromatosis Mx1-22AMLPM_1799
Cross-references
UniProtQ9CBM7
Gene OntologyMetabolic process, Metal ion binding, Methylmalonyl-coa mutase activity, Cobalamin binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE METHYLMALONYL-CoA MUTASE LARGE SUBUNIT MUTB (MCM)
CommentsML1799c, len: 758 aa. Probable mutB, methylmalonyl-CoA mutase (EC 5.4.99.2). Similar to M. tuberculosis mutB Rv1493 SW:MUTB_MYCTU (P71774) (750 aa), Fasta scores: E(): 0, 88.9% identity in 748 aa overlap, and many other methylmalonyl-CoA mutase alpha-subunit e.g. Streptomyces cinnamonensis SW:MUTB_STRCM (Q05065) (733 aa), Fasta scores: E(): 0, 74.7% identity in 726 aa overlap. Also similar to ML1800. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21779102180186-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1799c|mutB
MTVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHWHTPEGIDVKPVYIAADRAAAEAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAGLDIDTFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGWSLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAELSGAAGAHGRAGDNLLALAINAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGEAGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRGQKVVATAFADLGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDFDELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT
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