Gene ML1800c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemutA
Gene length1911 bp
IdentifierML1800c
Location 2180192 bp
Protein summary information
Molecular mass67155.0 Da
Isoelectric point4.79
Protein length637 amino acids
Structural information
PFAMPF01642
Orthologs
M. tuberculosis H37RvRv1492
M. lepromatosis Mx1-22AMLPM_1800
Cross-references
UniProtQ9CBM6
Gene OntologyLactate fermentation to propionate and acetate, Metal ion binding, Methylmalonyl-coa mutase activity, Cobalamin binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE METHYLMALONYL-CoA MUTASE SMALL SUBUNIT MUTA (MCM)
CommentsML1800c, len: 636 aa. Probable mutA, methylmalonyl-CoA mutase small subunit. Similar to M. tuberculosis mutA Rv1492 SW:MUTA_MYCTU (P71773) (615 aa), Fasta scores: E(): 0, 75.3% identity in 636 aa overlap, and many other methylmalonyl-CoA mutase beta-subunit e.g. Streptomyces cinnamonensis SW:SW:MUTA_STRCM (Q05064) (616 aa), Fasta scores: E(): 0, 42.7% identity in 626 aa overlap. Also similar to ML1799 from M. leprae. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21801922182102-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1800c|mutA
VFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYTVFDELPESSLPGEWPYRRGGDALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAALAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDAGADYVEACDAVLALLARLDSSRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASATWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIAEVAGDPEGGAAVVHAETSLPMMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPGGFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFVENLTEQLAQQAWQHFQAIETYGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAGNLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAINLGSVDAPGVVQAVAQAGFMAGSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPEKALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA
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