Gene ML1806c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIS ISOZYME IS INVOLVED IN MYCOLIC ACID BIOSYNTHESIS. SECOND REDUCTIVE STEP IN FATTY ACID BIOSYNTHESIS. INVOLVED IN THE RESISTANCE AGAINST THE ANTITUBERCULOSIS DRUGS ISONIAZID AND ETHIONAMIDE [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + NAD(+) = TRANS-2,3-DEHYDROACYL-[ACYL-CARRIER PROTEIN] + NADH]. |
| Product | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) |
| Comments | ML1806c, len: 269 aa. Probable inhA, NADH-dependent enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9). Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa), Fasta scores: E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa), Fasta scores: E(): 1.2e-17, 33.2% identity in 268 aa overlap. Also similar to ML1807 from M. leprae. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2186802 | 2187611 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1806c|inhA
MAGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPLIELDVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIHISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAKTVCALLSEWLPATTGSIIYADGGASTQLL
Bibliography
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