Gene ML1814 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameacn
Gene length2835 bp
IdentifierML1814
Location 2195139 bp
Protein summary information
Molecular mass103247.0 Da
Isoelectric point5.2
Protein length945 amino acids
Structural information
PFAMPF00330, PF00694
Orthologs
M. tuberculosis H37RvRv1475c
M. lepromatosis Mx1-22AMLPM_1814
Cross-references
UniProtQ9CBL3
Gene OntologyMetabolic process, 4 iron, 4 sulfur cluster binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN (Citrate hydro-lyase) (Aconitase)
CommentsML1814, len: 944 aa. Probable acn, iron-regulated aconitate hydratase (EC 4.2.1.3). Similar to M. tuberculosis aconitate hydratase Rv1475c TR:O53166 (EMBL:AL021184) (943 aa), Fasta scores: E(): 0, 86.8% identity in 948 aa overlap, and to many others e.g. Bacillus subtilis aconitate hydratase SW:ACON_BACSU (P09339) (908 aa), Fasta scores: E(): 0, 51.1% identity in 940 aa overlap. Also similar to ML1685 from M. leprae. Contains 2 Pfam matches to entry PF00330 aconitase, Aconitase family (aconitate hydratase). Contains Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain. Contains PS01244 Aconitase family signature 2. Contains PS00450 Aconitase family signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21951392197973+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1814|acn
VISSKDSVNSFSARDTLKIGDNSYQIYRLDAVSNTKRLPYSLKVLAENLLRNEDGKNITKDHIEAIANWDRQAEPSIEIQYTPARIVMQDFTGVPCIVDLATMREAIGDLGGNPEKVNPLARVDLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFNDFKVVPPGTGIVHQVNIEYLASVVMTQENTQGTVVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPWVVGFKLSGEIQPGVTATDVVLTVTEMLRRHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETINYLRFTGRTPEQVALVEGYAKEQGMWHDPKNEPTFSEYLELNLSDVVPSISGPKRPQDRICLAQAKSTFRAQIPKYVDGSSLHNQHSKLDEVVEETCPASDPGKLSFTNNDEVVMQSAAAHANGRVSNPVRIKTQELGEFVLDHGAVVIAAITSCTNTSNPEVMLCAALLARNAVEKGLASKPWVKTTMAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAINYNNLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFESQPLDTDKNGKAVYLKDIWPSQKDVTDTIASAINQEMFTKNYADVFKGDERWRNLPTPSGNTFDWEQNSTYVRKPPYFEGMSVEPKPVRNITGARVLALLDDSVTTDHISPASTIKPGTPAAQYLDTHGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNMLLNGVAGGYTRDFTKPGAPQAFIYDAAQNYAAENIPLVVLSGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPQGESASSLGLDGTEVFEINGIDVFNNGKTPKTVHVKASKASGTTVTFDALVRIDTPGEADYYRNGGILHYVLRNILKSN
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