Gene ML1832c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIS SMALL UBIQUITOUS ENZYME IS ESSENTIAL IN INTRACELLULAR NUCLEOTIDE METABOLISM, IN ADDITION IT HAS BEEN FOUND TO ACTS AS BOTH A NUCLEOSIDE MONO- AND DI-PHOSPHATE KINASE SUGGESTING IT MAY HAVE A ROLE IN RNA AND DNA BIOSYNTHESIS [CATALYTIC ACTIVITY: ATP + AMP = ADP + ADP]. |
| Product | PROBABLE ADENYLATE KINASE KAD (ATP-AMP TRANSPHOSPHORYLASE) |
| Comments | ML1832c, len: 181 aa. Probable kad, adenylate kinase (EC 2.7.4.3). Similar to M. tuberculosis adenylate kinase kad Rv0733 SW:KAD_MYCTU (O53796) (181 aa), Fasta scores: E(): 0, 83.4% identity in 181 aa overlap, and to many thers e.g. Bacillus subtilis adenylate kinase SW:KAD_BACSU (P16304) (217 aa), Fasta scores: E(): 2.9e-20, 39.3% identity in 211 aa overlap. Contains Pfam match to entry PF00406 adenylatekinase, Adenylate kinase. Contains PS00113 Adenylate kinase signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2220221 | 2220766 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1832c|kad
VRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVPADLTNQLVDDRLNKSDTVDGFILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVVLERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELKTIDAIGTMDEVFARALHALGK
Bibliography
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