Gene ML1889c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN BASE EXCISION REPAIR. ENDONUCLEASE IV PLAYS A ROLE IN DNA REPAIR. IT CLEAVES PHOSPHODIESTER BONDS AT APURINIC OR APYRIMIDINIC SITES (AP SITES) TO PRODUCE NEW 5' ENDS THAT ARE BASE-FREE DEOXYRIBOSE 5-PHOSPHATE RESIDUES [CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products]. |
| Product | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) |
| Comments | ML1889c, len: 252 aa. Probable end, endonuclease IV (EC 3.1.21.2). Similar to Mycobacterium tuberculosis probable endonuclease IV nfo or end or Rv0670 or MTCI376.04C SW:END4_MYCTU (O86366) (252 aa) fasta scores: E(): 0, 85.6% identity in 250 aa. Similar to many putative endonucleases. Previously sequenced as SW:END4_MYCLE (P30770). Contains Pfam match to entry PF01261 AP_endonulease2, AP endonuclease family 2. Contains PS00730 AP endonucleases family 2 signature 2. Contains PS00731 AP endonucleases family 2 signature 3. Contains PS00729 AP endonucleases family 2 signature 1. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2268194 | 2268952 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1889c|end
VLIGSHVSSTDPLAAAEVEGADVVQIFLGNPQSWKAPTLRSDADVLKATALPVYVHAPYLINVASANSRVRIPSRKILQQTCDAAADIGAAAVVVHGGYVADDNDLEDGFQRWRKALDQLQTDVPVYLENTAGGDHAMARRFDTIARLWDVIGETGIGFCLDTCHAWAAGEGLIHVVDRIKAITGRIDLVHCNDSKDEAGSGRDRHANLGSGQIDAELLVAAVKVAGAPVICETAEEGRKDDIAFLREKTSG
Bibliography
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