Gene ML1903
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN MYCOLIC ACIDS MODIFICATION. CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a major constituent of the mycobacterial cell wall complex. Methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; Olefinic mycolic acid methyl transferase. |
| Product | METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) |
| Comments | ML1903, len: 298 aa. Probable mmaA4, methyl mycolic acid synthase (EC 2.1.1.-). Similar to M. tuberculosis methyl mycolic acid synthase 4 Rv0642c TR:P72028 (EMBL:U66108) (301 aa), Fasta scores: E(): 0, 87.5% identity in 296 aa overlap, and to many others e.g. M. tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 SW:CFA1_MYCTU (Q11195) (287 aa), Fasta scores: E(): 0, 57.0% identity in 286 aa overlap. Also similar to ML2459, ML2426 and ML2334 from M. leprae. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2287638 | 2288534 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1903|mmaA4
MTEQPTGPTKTRTRSEDIQAHYDLSNEFFALFQDPTRTYSCAYFEPPDLTLEEAQYAKIDLNLNKLDLKPGMTLLDIGCGWGTTMRRAVEKYDVKVIGLTLSKNQHARCEQVLTALESNRSRQVRLQGWEDFTEPVDRIVSIEAFEHFGHENYDDFFKRCFNIMPSDGRMTVQSSVSYHPFDMAARGKKLSFETARFIKFIITEIFPGGRLPSTKMMVEHGEKAGFTVSEPLSLQSHYVKTLRIWGDTLESNRAKAIEVTSEAVYNRYMKYLRGCAHYFSDEMLDCSLVTYLKPGALD
Bibliography
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