Gene ML1940 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namexseA
Gene length1287 bp
IdentifierML1940
Location 2326360 bp
Protein summary information
Molecular mass46290.0 Da
Isoelectric point9.07
Protein length429 amino acids
Structural information
PFAMPF01336, PF02601
Orthologs
M. tuberculosis H37RvRv1108c
M. lepromatosis Mx1-22AMLPM_1940
Cross-references
UniProtQ9X783
Gene OntologyCytoplasm, Exodeoxyribonuclease vii activity, Exodeoxyribonuclease vii complex, Nucleic acid binding, Dna catabolic process
Enzyme Classification3.1.11.6
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionBIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'- TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD 5'-PHOSPHOMONONUCLEOTIDES]
ProductPROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE VII LARGE SUBUNIT)
CommentsML1940, len: 428 aa. Probable xseA, exonuclease VII large subunit (EC 3.1.11.6). Similar to M. tuberculosis exonuclease VII large subunit xseA Rv1108c, and to many others e.g. Escherichia coli exodeoxyribonuclease large subunit SW:EX7L_ECOLI (P04994) (456 aa), Fasta scores: E(): 1.7e-28, 31.8% identity in 425 aa overlap.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23263602327646+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1940|xseA
VTEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAKTVFMVLRDPAADISLIVTCSRDFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIRAVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIGIITGRASAAERDVTTVASARWPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCRAIAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQALRNWVSREQRTLVQLRSRPVLAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGHLATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVDDAPTGTRLRVRVSDGAIVAVSEGRADGP
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