Gene ML1942 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1942
Gene length1131 bp
IdentifierML1942
Location 2327950 bp
Protein summary information
Molecular mass41163.1 Da
Isoelectric point7.28
Protein length377 amino acids
Structural information
PFAMPF01073
Orthologs
M. tuberculosis H37RvRv1106c
M. lepromatosis Mx1-22AMLPM_1942
Cross-references
UniProtQ7AQ16
Gene OntologyBinding, Steroid biosynthetic process, 3-beta-hydroxy-delta5-steroid dehydrogenase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CHOLESTEROL DEHYDROGENASE
CommentsML1942, len: 376 aa. Probable cholesterol dehydrogenase (EC 1.1.1.-). Similar to M. tuberculosis cholesterol dehydrogenase Rv1106c TR:O53454 (EMBL:AL021897) (370 aa), Fasta scores: E(): 0, 75.5% identity in 375 aa overlap, and to Nocardia sp NAD(P)-dependent cholesterol dehydrogenase TR:Q03704 (EMBL:D90244) (364 aa), Fasta scores: E(): 0, 71.0% identity in 366 aa overlap. Also similar to ML0204 and ML1964 from M. leprae. Contains Pfam match to entry PF01073 3Beta_HSD, 3-beta hydroxysteroid dehydrogenase/isomerase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23279502329080+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1942|ML1942
MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQVRSFDRAPMPLPQHPQLEVLQGDITDATVCTTAMDSIDTVFHTAAIIELMGGASVTDEYRQRSYTVNVGGTENLLRAGQKSGVKRFVYTASNSVVMGGTPITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIRPSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLILAAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRLVRNVMAVWQRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
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