Gene ML1947
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE FUMARASE FUM (Fumarate hydratase) |
| Comments | ML1947, len: 474 aa. Probable fum, fumarase (EC 4.2.1.2). Similar to M. tuberculosis fumarase Rv1098c fum TR:O53446 (EMBL:AL021897) (474 aa), Fasta scores: E(): 0, 89.5% identity in 467 aa overlap, and to many others e.g Homo sapiens fumarate hydratase, mitochondrial precursor SW:FUMH_HUMAN (P07954) (510 aa), Fasta scores: E(): 0, 52.1% identity in 461 aa overlap. Also similar to ML1413 and ML2230 from M. leprae. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2333631 | 2335055 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1947|fum
MKRTQFMADSAEYRIEHDTMGEVRVPAIALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLASEKANAIIAAAATIADGYHDDQFPIDVFQTGSGTSSNMNTNEVIGSIAAANGVPVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLIPALQELHAALATKSSEWHTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDGFGAKVVEALIATTGLTELRPAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRLMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESYQLLTNVSRLFAERCIKGLSANIEHLRELAESSQSIVTPLNSAIGYEEAAAVVKQALKERKTLRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPADS
Bibliography
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