Gene ML1953c (glyA1) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameglyA
Gene length1281 bp
IdentifierML1953c
Location 2340161 bp
Protein summary information
Molecular mass45224.4 Da
Isoelectric point6.32
Protein length427 amino acids
Structural information
PFAMPF00464
Orthologues
M. tuberculosisRv1093
Cross-references
UniProtQ9X794
Gene OntologyCytoplasm, Glycine hydroxymethyltransferase activity, Glycine metabolic process, One-carbon metabolic process, Pyridoxal phosphate binding, L-serine metabolic process
Enzyme Classification2.1.2.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Serine hydroxymethyltransferase 1 GlyA
CommentsML1953c, len: 426 aa. Probable glyA, Serine hydroxymethyltransferase 1 (EC 2.1.2.1). Similar to M. tuberculosis serine hydroxymethyltransferase glyA1 Rv1093 SW:GLA1_MYCTU (O53441) (426 aa), Fasta scores: E(): 0, 89.9% identity in 426 aa overlap, and to many others e.g. Escherichia coli serine hydroxymethyltransferase SW:GLYA_ECOLI (P00477) (417 aa), Fasta scores: E(): 0, 53.5% identity in 415 aa overlap. Contains Pfam match to entry PF00464 SHMT, Serine hydroxymethyltransferase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23401612341441-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1953c|glyA
MVAPLAEVDPDIAELLGKELGRQRDTLEMIASENFVPRSVLQAQGSVLTNKYAEGLPGRRYYDGCEHVDVVENIARDRAKALFGADFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYETGFYGVDATTHLIDMDAVRAKALEFRPKVLIAGWSAYPRILDFAAFRSIADEVGAKLWVDMAHFAGLVAVGLHPSPVPHADVVSTTVHKTLGGGRSGLILGKQEFATAINSAVFPGQQGGPLMHVIAGKAVALKIATTPEFTDRQQRTLAGARILADRLTAADVTKAGVSVVSGGTDVHLVLVDLRNSPFDGQAAEDLLHEVGITVNRNVVPNDPRPPMVTSGLRIGTPALATRGFGEAEFTEVADIIATVLTTGGSVDVAALRQQVTRLARDFPLYGGLEDWSLAGR
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