Gene ML1964 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namermlB
Gene length1002 bp
IdentifierML1964
Location 2348340 bp
Protein summary information
Molecular mass37780.1 Da
Isoelectric point6.26
Protein length334 amino acids
Structural information
PFAMPF01370
Orthologues
M. tuberculosisRv3464
Cross-references
UniProtQ9CBH7
Gene OntologyDtdp-glucose 4,6-dehydratase activity, Nucleotide-sugar metabolic process, Coenzyme binding
Enzyme Classification4.2.1.46
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductdTDP-GLUCOSE 4,6-DEHYDRATASE RMLB
CommentsML1964, len: 333 aa. Probable rmlB, dTDP-glucose 4,6-dehydratase (EC ). Similar to M. tuberculosis dTDP-glucose 4,6-dehydratase rmlB Rv3464 TR:O06329 (EMBL:Z95390) (331 aa), Fasta scores: E(): 0, 84.0% identity in 331 aa overlap, and to others e.g. Streptococcus pneumoniae DTDP-glucose-4,6-dehydratase cpsN TR:O54611 (EMBL:AF030364) (349 aa), Fasta scores: E(): 0, 59.9% identity in 334 aa overlap. Also similar to ML0204, ML0751, ML1942 and ML2428 from M. leprae. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23483402349341+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1964|rmlB
LTMRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLADVDHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRTNVIGTFTILEAVRHHSVRLHHISTDEVYGDLELDEPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAVEARYEERGR
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