Gene ML1965
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN dTDP-L-RHAMNOSE BIOSYNTHESIS, WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS: CONVERSION OF dTDP-4-KETO-6-DEOXY-D-GLUCOSE TO DTDP-4-KETO-RHAMNOSE [CATALYTIC ACTIVITY: dTDP-4-DEHYDRO-6-DEOXY-D-GLUCOSE = dTDP-4-DEHYDRO-6-DEOXY-L-MANNOSE]. |
| Product | dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE) |
| Comments | ML1965, len: 202 aa. Probable rmlC, dTDP-4-dehydrorhamnose 3,5-epimerase. Similar to M. tuberculosis dTDP-4-dehydrorhamnose 3,5-epimerase rmlC Rv3465 TR:O06330 (EMBL:Z95390) (202 aa), Fasta scores: E(): 0, 75.4% identity in 199 aa overlap, and to many others e.g. Streptomyces griseus DTDP-4-dehydrorhamnose 3,5-epimerase SW:STRM_STRGR (P29783) (200 aa), Fasta scores: E(): 0, 45.6% identity in 193 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2349343 | 2349951 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1965|rmlC
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRGLHFAQVPPSQAKYVTCVTGSVFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVVDGVDTHLSKRDATAPNLDDIRASGLLPTWDETQNFIANLGSK
Bibliography
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