Gene ML1974 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1974
Gene length1719 bp
IdentifierML1974
Location 2358459 bp
Protein summary information
Molecular mass61530.9 Da
Isoelectric point10.57
Protein length573 amino acids
Structural information
PFAMPF00324
Orthologs
M. tuberculosis H37RvRv1979c
M. lepromatosis Mx1-22AMLPM_1974
Cross-references
UniProtQ9CBH5
Gene OntologyAmino acid transport, Membrane, Amino acid transmembrane transporter activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE CONSERVED PERMEASE
CommentsML1974, len: 572 aa. Possible conserved permease. Similar to M. tuberculosis probable permease Rv1979c SW:YJ79_MYCTU (Q10875) (481 aa), Fasta scores: E(): 0, 76.8% identity in 462 aa overlap, and to e.g. Arabidopsis thaliana putative amino acid transporter TR:Q9SQZ0 (EMBL:AC011560) (584 aa), Fasta scores: E(): 2.1e-13, 23.0% identity in 508 aa overlap. Also similar to ML1304 and ML1305 from M. leprae. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23584592360177+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1974|ML1974
VFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQLPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWSIRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAGPFAPIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAITASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSRSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK
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