Gene ML1996 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenrp
Gene length4206 bp
IdentifierML1996
Location 2383327 bp
Protein summary information
Molecular mass152271.0 Da
Isoelectric point5.15
Protein length1402 amino acids
Structural information
PFAMPF00501, PF07993
Orthologs
M. tuberculosis H37RvRv0101
M. lepromatosis Mx1-22AMLPM_1996
Cross-references
UniProtQ50177
Gene OntologyBinding, Metabolic process, L-aminoadipate-semialdehyde dehydrogenase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)
CommentsML1996, len: 1401 aa. Possible nrp, peptide synthase. Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa), Fasta scores: E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa), Fasta scores: E(): 5.6e-20, 31.2% identity in 382 aa overlap. Also similar to ML1051 and ML0243 from M. leprae. Similar to ML2665 a possible pseudogene similar to M. tuberculosis nrp. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23833272387532+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1996|nrp
VTAPNTRRVDRVPLSRSQQNIYNGMLQDNDPALYFIGKSYRFHQLELSVFLAALEATILKNPGQLCVLEAPSTEGDYPDLVPRLQFGDIVRVRSDEQPQTDSRDYDLMHAWSPDILAKPLVRYTVRTDKNGFVARLDVFTHHILVDGGAIRIIEENLAHHLDTDNRLEIPCIRQALDKLAEAHRREATKVEESLQRLANVVQRELADEVRNGGYGQVSNDAPGNAARGVLHESMIICGKAFDNIIALSETKQVPLNILVATAAVAVDASLRQSTEGLLVHAVDNRFGDPYLDVATCLVNSVAHSIRFPPFASVQDVVRTLDRSYVKAIRLRWLREEYYRRIYLALNQTSHIEALTLNFIREPCAPGLRPFLSEVPTVTDIGPVEGMTVACVLNEDERTLDLSIWNRVDLPQGKSCTRVAKRIAAALELMAAAWDQPIAMIVNEWFGISSDGALCLGNEVTQTTRPLAPAWFLDPGGSVHLTVDKRRYVHPWIAWLVRGSVVPGDVLVFTDDNTDKTIDLLIACHLAGCGYSVCDTVAEVPLRAKAITDHGGGVSARVIDVAATQLAVTPDNEQSKLADKLIKQAAQDISLADKTAYIMPTSGSTGQPKLVQVSHGSLALFCDAVRNAYGWGAHDTILQCAPLTSDISVEEIFGGAICGSKLVRSTAMKTGDLAELARDIFVQRATVIDLPTAVWHLLCDHSDAIDEINRSCLRQIVIGGEAVRPCAVDKWIDSGASQGISLMSTYGPTETTVVVTYLPIVCAPMTVESDARLRLGWPIVPNTVFIAFGELVIVGDLVSVGYLGIDSRNFGTVTTTDGSCRRAFATADCVILDDEGFPVFSGRKDAVVKISGKRVDTAELIRRISTDPNVSDVAVEVYNGRLGVWFETKLTREGVDDAAAATRSRLILASLGVSSFFVVGVPCIPRKPNGKIDRDNLLVMPQLVDSVQNYAGSGEGAAGLAEIWSRHLGRAILPDSSLLDEGIGSVDLIRILPDTRRHLGRHLSLLDLISADNAANLTAAQTANVWMDVGTAAEIERDLASLCRQRNATEFSVKQTRNSHQKQAIVVLGASGILGTGFAQAVLDLRQSGVLCPEVVLATRARLPEGDPWTALQGVDGVRIERISFENGPGELEALIRDTDAGTLVNGVGNTNMLVPYRELRLANVELVSAIVDICASYSTRLVHLSSFVVNADVTVPQVTDPRETPYPYAASKSLAELVVAGSPSALDFTIVRLPRVLGEDYQLRNSSDILLSIVDACIALRAYPSATVTEEVTTGRAAAKAILGVVSALARSGQLGSGISVVRGEAVAYADFLSEFASDELNMAEWKYRLDQSDWAKRNPRRWSVIDAWFTLGMMFEMRSYAEYPTMALGVESVAELAAPPESIRALLAHGCSQPLKYTGR
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