Gene ML2000c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB |
| Comments | ML2000c, len: 750 aa. Probable ctpB, cation-transporter P-type ATPase B (EC 3.6.3.-). Similar to M. tuberculosis cation-transporting ATPase ctpB SW:CTPB_MYCTU (Q10877) (752 aa), Fasta scores: E(): 0, 77.0% identity in 752 aa overlap, and to many others e.g. Bacillus subtilis potential copper-transporting ATPase YVGX SW:ATCU_BACSU (O32220) (803 aa), Fasta scores: E(): 0, 39.8% identity in 744 aa overlap. Also similar to ML1987, ML0747 and ML2671 from M. leprae. Contains Pfam matches to entries PF00403 HMA, Heavy-metal-associated domain and PF00122 E1-E2_ATPase, E1-E2 ATPase. Also contains Prosite hits to PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00154 E1-E2 ATPases phosphorylation site, PS01047 Heavy-metal-associated domain and PS01229 Hypothetical cof family signature 2. Contains multiple possible membrane spanning hydrophobic domains. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2391324 | 2393576 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2000c|ctpB
VTASLVEDTNNNHESVRRIQLDVAGMLCAACASRVETKLNKIPGVRASVNFATRVATIDAVDVAVDELRQVIEQAGYRATAHAESAVEEIDPDADYARNLLRRLIVAALLFVPLADLSTMFAIVPTNRFPGWGYLLTALAAPIVTWAAWPFHRVALRNARYRAASMETLISAGILAATGWSLSTIFVDKEPRQTHGIWQAILHSDSIYFEVAAGVTVFVLAGRFFEARAKSKAGSALRALAARGAKNVEVLLPNGAELTIPAGELKKQQHFLVRPGETITADGVVIDGTATIDMSAITGEARPVHASPASTVVGGTTVLDGRLVIEATAVGGDTQFAAMVRLVEDAQVQKARVQHLADRIAAVFVPMVFVIAGLAGASWLLAGASPDRAFSVVLGVLVIACPCTLGLATPTAMMVASGRGAQLGIFIKGYRALETINAIDTVVFDKTGTLTLGQLSVSTVTSTGGWCSGEVLALASAVEAASEHSVATAIVAAYADPRPVADFVAFAGCGVSGVVAEHHVKIGKPSWVTRNAPCDVVLESARREGESRGETVVFVSVDGVACGAVAIADTVKDSAADAISALCSRGLHTILLTGDNQAAARAVAAQVGIDTVIADMLPEAKVDVIQRLRDQGHTVAMVGDGINDGPALACADLGLAMGRGTDVAIGAADLILVRDSLGVVPVALDLARATMRTIRINMIWAFGYNVAAIPIASSGLLNPLIAGAAMAFSSFFVVSNSLRLSNFGLSQTSD
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