Gene ML2053c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameadhA
Gene length1008 bp
IdentifierML2053c
Location 2441104 bp
Protein summary information
Molecular mass35489.2 Da
Isoelectric point5.3
Protein length336 amino acids
Structural information
PFAMPF00107, PF08240
Orthologs
M. tuberculosis H37RvRv1862
M. lepromatosis Mx1-22AMLPM_2053
Cross-references
UniProtQ9CBF1
Gene OntologyOxidoreductase activity, Zinc ion binding, Oxidation-reduction process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable alcohol dehydrogenase AdhA
CommentsML2053c, len: 335 aa. Probable adhA, alcohol dehydrogenase (EC 1.1.1.1). Similar to Mycobacterium tuberculosis adhA or Rv1862 or MTCY359.11 TR:P95153 (EMBL:Z83859) (346 aa) fasta scores: E(): 0, 84.5% identity in 336 aa. Similar to Rhizobium meliloti alcohol dehydrogenase adhA SW:ADHA_RHIME (O31186) (340 aa) fasta scores: E(): 6.3e-26, 33.1% identity in 344 aa and many putative alcohol dehydrogenases. Also similar to ML1730, ML1784 and ML2025 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24411042442111-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2053c|adhA
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHVTPGHEVVGEVLGVGSDVDAAAGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGWDVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGYRSLLRSELPPGGRLGIYGFGGSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGDLVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHIAVTTPEYPLEQADQALTDLSVGRISGAAVLLA
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