Gene ML2065 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegnd1
Gene length1452 bp
IdentifierML2065
Location 2452186 bp
Protein summary information
Molecular mass52004.8 Da
Isoelectric point6.15
Protein length484 amino acids
Structural information
PFAMPF00393, PF03446
Orthologs
M. tuberculosis H37RvRv1844c
M. lepromatosis Mx1-22AMLPM_2065
Cross-references
UniProtQ9CBE9
Gene OntologyPentose-phosphate shunt, Phosphogluconate dehydrogenase (decarboxylating) activity, Nadp binding
Enzyme Classification1.1.1.44
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1
CommentsML2065, len: 483 aa. Probable gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to Mycobacterium tuberculosis cosmid gnd TR:P95165 (EMBL:AL008609) fasta scores: E(): 0, 86.8% in 485 aa and to Bacillus subtilis 6-phosphogluconate dehydrogenase, decarboxylating II SW:6PG2_BACSU (P80859; P54546) fasta scores: E(): 0, 55.7% in 465 aa. Contains Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenases.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24521862453637+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2065|gnd1
MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGSVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPYFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV
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