Gene ML2066
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) |
| Comments | ML2066, len: 478 aa. Probable guaB1, inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase Rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Also similar to ML0387 and ML0388 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2453707 | 2455143 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2066|guaB1
MRFLDGHQPRFDLTYKDVFIVPHRSDVASRFDVDLSTYDGSGTTIPVVVANMTTVAGQRMAETVARRGGLVILPQDLPIATVQQAVEFVKSRDLVIDTPVLLTPNDSVSDATTLIHKRAHGVAVVAFEGRPIGLVRESSCLGVDRFTRVRDVATTDFVTAPVGTDPRKIFDLLEHAPIDVAVLTNADGTLAGVLTRTGAIRAGIYTPATDARGRLRIGAAVGINGDVAGKAQSLAEAGVDVLVVDTAHGYQVKTLEAIKCVASLNLGVPLVAGNVVSAEGTRELLNAGATIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARKLNRHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRHDQPYKESYGMASKRAVVARTVADSSFDRARKALFDEGISTSRMGLDPDHGGVEDLIDHITSGVRSTCTYVGASTLAELHEKAVVGVQSAAGFAEGHPLPSGW
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