Gene ML2066 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameguaB1
Gene length1437 bp
IdentifierML2066
Location 2453707 bp
Protein summary information
Molecular mass50383.2 Da
Isoelectric point6.84
Protein length479 amino acids
Structural information
PFAMPF00478, PF00571
Orthologues
M. tuberculosisRv1843c
Cross-references
UniProtO32912
Gene OntologyOxidation-reduction process, Imp dehydrogenase activity
Enzyme Classification1.-.-.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)
CommentsML2066, len: 478 aa. Probable guaB1, inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase Rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Also similar to ML0387 and ML0388 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24537072455143+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2066|guaB1
MRFLDGHQPRFDLTYKDVFIVPHRSDVASRFDVDLSTYDGSGTTIPVVVANMTTVAGQRMAETVARRGGLVILPQDLPIATVQQAVEFVKSRDLVIDTPVLLTPNDSVSDATTLIHKRAHGVAVVAFEGRPIGLVRESSCLGVDRFTRVRDVATTDFVTAPVGTDPRKIFDLLEHAPIDVAVLTNADGTLAGVLTRTGAIRAGIYTPATDARGRLRIGAAVGINGDVAGKAQSLAEAGVDVLVVDTAHGYQVKTLEAIKCVASLNLGVPLVAGNVVSAEGTRELLNAGATIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARKLNRHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRHDQPYKESYGMASKRAVVARTVADSSFDRARKALFDEGISTSRMGLDPDHGGVEDLIDHITSGVRSTCTYVGASTLAELHEKAVVGVQSAAGFAEGHPLPSGW
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