Gene ML2083c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameilvG
Gene length1647 bp
IdentifierML2083c
Location 2475220 bp
Protein summary information
Molecular mass57620.6 Da
Isoelectric point5.45
Protein length549 amino acids
Structural information
PFAMPF00205, PF02775, PF02776
Orthologs
M. tuberculosis H37RvRv1820
M. lepromatosis Mx1-22AMLPM_2083
Cross-references
UniProtO32923
Gene OntologyThiamine pyrophosphate binding, Transferase activity, Magnesium ion binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)
CommentsML2083c, len: 548 aa. Probable ilvG, Acetolactate synthase (EC 4.1.3.18). Similar to Mycobacterium tuberculosis probable acetolactate synthase SW:ILVG_MYCTU (Q50613) fasta scores: E(): 0, 86.1% in 548 aa, and to Bacillus subtilis acetolactate synthase large subunit SW:ILVB_BACSU (P37251; P94564) fasta scores: E(): 1.2e-32, 28.5% in 543 aa. Also similar to ML1696, ML2167 and ML0354 from M. leprae. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24752202476866-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2083c|ilvG
MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTAAFAAEGWSKVTRQPGVAVLTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPSGVGFVDFPMDYVFSMADDVGGGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIPVLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVADRAEPDRDYPRPVAAGLYGDLPAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDDRLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVAYPRRSNLA
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