Gene ML2124 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameprrB
Gene length1341 bp
IdentifierML2124
Location 2524876 bp
Protein summary information
Molecular mass47796.3 Da
Isoelectric point6.97
Protein length447 amino acids
Structural information
PFAMPF00512, PF00672, PF02518
Orthologs
M. tuberculosis H37RvRv0902c
M. lepromatosis Mx1-22AMLPM_2124
Cross-references
UniProtO33071
Gene OntologyIntegral to membrane, Peptidyl-histidine phosphorylation, Plasma membrane, Phosphorelay sensor kinase activity, Phosphorelay signal transduction system, Atp binding
Enzyme Classification2.7.13.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductTWO COMPONENT SENSOR HISTIDINE KINASE PRRB
CommentsML2124, len: 446 aa. Probable prrB, two component sensor histidine kinase (EC 2.7.3.-). Similar to Mycobacterium tuberculosis probable sensor-like histidine kinase Rv0902c SW:Y902_MYCTU (Q10560) fasta scores: E(): 0, 92.4% in 446 aa, and to Escherichia coli sensor protein cpxa SW:CPXA_ECOLI (P08336) fasta scores: E(): 7e-14, 28.9% in 301 aa. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains Pfam match to entry PF00512 signal, Histidine kinase.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25248762526216+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2124|prrB
MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRKLDEAAGFAIPFVPRGLDEIPRSPNDQDAIITVRRGNLVKSNFDITLPKLTNDYADTYLRGVRYRVRTVEIPAPEPTSIAVGATYDATVAETNNLHRRVLLICGFAIAAAAVFAWLLAAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLATLDLADDQRKEVLGDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAVANAVKHGGATRVQLSAVSSRAGVEIAVDDNGSGVPEDERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLETSPLGGARLLLRISAPS
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