Gene ML2134c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefprB
Gene length1668 bp
IdentifierML2134c
Location 2535820 bp
Protein summary information
Molecular mass59712.2 Da
Isoelectric point7.17
Protein length556 amino acids
Structural information
PFAMPF00037, PF07992
Orthologs
M. tuberculosis H37RvRv0886
M. lepromatosis Mx1-22AMLPM_2134
Cross-references
UniProtO33064
Gene OntologyElectron carrier activity, Electron transport chain, Ferredoxin-nadp+ reductase activity, Iron ion binding, Transport, 4 iron, 4 sulfur cluster binding
Enzyme Classification1.18.1.2
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)
CommentsML2134c, len: 555 aa. Probable fprB, ferredoxin, ferredoxin-NADP reductase (EC 1.18.1.2). Similar to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase Rv0886 SW:FPRB_MYCTU (Q10547) fasta scores: E(): 0, 76.6% in 560 aa, and to Homo sapiens NADPH:adrenodoxin oxidoreductase precursor SW:ADRO_HUMAN (P22570; Q13716) fasta scores: E(): 2.9e-30, 37.4% in 484 aa. Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00198 4Fe-4S ferredoxins.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25358202537487-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2134c|fprB
MPYIITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCGACVSACPVGAIASDTRLAPKQLPFIEINASYYPARPIDLKLPPTSKLAPVIPAAQVHVRRRPLTVAIVGSGPAAMYAADELLTQPGVWVNVFEKLPTPYGLVRAGLAPDHQNTKKVTELFDRVAEHRRFRFFLNVEIGRHLSHDELLAHHHAVLYAVGAPDDRRLNIDGMGIPGTGTATELVAWINAHPDFAYLPVDLSHERVVVIGNGNVALDVARLLTADPDNLARTDISEFALHVLGGSAVREVVVAARRGPAHSAFTLPELIGLKATSEVVLDAGDRKLVEGDFATVSDSLTRKKLEVLSSLVDSSKPTSRRRIRLAYQLTPKRVLGNQRATGVEFSVTGTEESRRFDAGLVLTSVGYRGKRIRDLPFDEEAAVIPNDGGRVVDPSRGRPMPGAYVAGWIKRGPTGFIGTNKLCSVQTVQAVVADFNAGWLTDPVAEPAELAKLVHARQPDTVDSVGWRAIDAAEIAQGSTEGRPRRKFTDVADMLAVAAGAPPLRLRALS
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