Gene ML2136
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES THE REVERSIBLE INTERCONVERSION OF PHOSPHOSERINE AND 2-OXOGLUTARATE TO 3-PHOSPHONOOXYPYRUVATE AND GLUTAMATE. REQUIRE BOTH IN THE MAJOR PHOSPHORYLATED PATHWAY OF SERINE BIOSYNTHESIS AND IN PYRIDOXINE BIOSYNTHESIS [CATALYTIC ACTIVITY: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate]. |
| Product | POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT) |
| Comments | ML2136, len: 376 aa. Possible serC, phosphoserine aminotransferase. Similar to Mycobacterium tuberculosis putative phosphoserine aminotransferase Rv0884c SW:SERC_MYCTU (Q10534) fasta scores: E(): 0, 87.5% in 376 aa, and to Methanosarcina barkeri phosphoserine aminotransferase SW:SERC_METBA (P52878) fasta scores: E(): 4.5e-12, 24.7% in 369 aa. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2538742 | 2539872 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2136|serC
MADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGRVRAGLAELFSLPDGYQVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNPFIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAVPVRRPTGSGGALIAIDATSGAGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIAVENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTPFVVDPALRSQVVGTIDFTDDVDAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPDDVRALTECVDWIVERL
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