Gene ML2167
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC |
| Comments | ML2167, len: 569 aa. Probable pdc, pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-). Highly similar to Mycobacterium tuberculosis Rv0853c putative pyruvate/indole-pyruvate carboxylase TR:O53865 (EMBL:AL022004) fasta scores: E(): 0, 79.2% in 543 aa, and to Enterobacter cloacae indole-3-pyruvate decarboxylase SW:DCIP_ENTCL (P23234) fasta scores: E(): 0, 47.8% in 550 aa, and to Saccharomyces cerevisiae pyruvate decarboxylase isozyme 3 SW:DCP3_YEAST (P26263) fasta scores: E(): 0, 38.1% in 557 aa. Also similar to ML1696 and ML2083 from M. leprae. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2575972 | 2577681 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2167|pdc
VTAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNAGYAADGYGRLRGISALVTTFGVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALHHSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSEVRKHKRPGYILLSTDVARFPTEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTADVVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFSQRIDPARTIDVGQYQSSVADKVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADTPSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEHRLPRGVTFIGQPLWGSIGYTLPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHGATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKLDLPSLLTALTRPAQDSNRIFQLPNPGWDN
Bibliography
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