Gene ML2167 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepdc
Gene length1710 bp
IdentifierML2167
Location 2575972 bp
Protein summary information
Molecular mass61113.4 Da
Isoelectric point5.43
Protein length570 amino acids
Structural information
PFAMPF00205, PF02775, PF02776
Orthologs
M. tuberculosis H37RvRv0853c
M. lepromatosis Mx1-22AMLPM_2167
Cross-references
UniProtQ9CBD6
Gene OntologyMagnesium ion binding, Thiamine pyrophosphate binding, Carboxy-lyase activity
Enzyme Classification4.1.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC
CommentsML2167, len: 569 aa. Probable pdc, pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-). Highly similar to Mycobacterium tuberculosis Rv0853c putative pyruvate/indole-pyruvate carboxylase TR:O53865 (EMBL:AL022004) fasta scores: E(): 0, 79.2% in 543 aa, and to Enterobacter cloacae indole-3-pyruvate decarboxylase SW:DCIP_ENTCL (P23234) fasta scores: E(): 0, 47.8% in 550 aa, and to Saccharomyces cerevisiae pyruvate decarboxylase isozyme 3 SW:DCP3_YEAST (P26263) fasta scores: E(): 0, 38.1% in 557 aa. Also similar to ML1696 and ML2083 from M. leprae. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25759722577681+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2167|pdc
VTAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNAGYAADGYGRLRGISALVTTFGVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALHHSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSEVRKHKRPGYILLSTDVARFPTEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTADVVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFSQRIDPARTIDVGQYQSSVADKVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADTPSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEHRLPRGVTFIGQPLWGSIGYTLPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHGATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKLDLPSLLTALTRPAQDSNRIFQLPNPGWDN
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